研究方向
植物发育生物学和合成基因组学
本实验室综合单细胞转录组分析、活体成像、分子遗传学、数学建模等方法，研究植物器官塑形。本实验室还开展合成基因组学研究，力图建立植物人工染色体技术。主要研究领域包括：
1. 叶片扁平化的建立机制：叶片是最基本的植物器官，通常是主要的光合作用场所。扁平宽大的形态有利于增大光合作用的面积，是常见的叶片特征。叶片的扁平化生长是伴随叶片发育过程逐渐形成的。本实验室的研究关注扁平化建立的调控机制，特别是植物激素生长素与生物力学在扁平化建立过程的作用。
2. 单细胞再生：分化的植物单细胞能够再生出完整植株。我们的前期工作发现细胞壁消化后增大基因表达的随机化，极少部分细胞激活了必需基因得以再生。本实验室将继续结合遗传筛选、单细胞组学分析解析再生过程的各个步骤。
3. 植物人工染色体：合成生命是生命科学的新前沿。物理学家费曼说过：“What I cannot create, I do not understand”。在细菌、酵母中，科学家已经获得了完全人工合成的染色体，不仅深化了对基因组的认识，更为快速进化、重编程代谢通路提供了技术平台。在更为复杂的多细胞生物中，人工合成基因组尚未突破。本实验室与合作者力图在植物中建立基因组操作的技术体系，实现突破。
代表性论文
1. Wang, Q., Marconi, M., Guan, C., Wabnik, K.* and Jiao, Y.* (2022) Polar auxin transport modulates early leaf flattening. Proc. Natl Acad. Sci. USA 119: e2215569119.
2. Peng, Z., Alique, D., Xiong, Y., Hu, J., Cao, X., Lü, S., Long, M., Wang, Y.*, Wabnik, K.* and Jiao, Y.* (2022) Differential growth dynamics control aerial organ geometry. Curr. Biol. 32: 4854-4868.e5.
3. Wang, Y., Du, F., Wang, J., Wang, K., Tian, C., Qi, X., Lu, F., Liu, X., Ye, X. and Jiao, Y.* (2022) Improving bread wheat yield through modulating an unselected AP2/ERF gene. Nat. Plants 8: 930-939.
4. Guan, C., Qiao, L., Xiong, Y., Zhang, L.* and Jiao, Y.* (2022) Coactivation of antagonistic genes stabilizes polarity patterning during shoot organogenesis. Sci. Adv. 8: eabn0368.
5. Hou, X., Wang, D., Cheng, Z., Wang, Y.* and Jiao, Y.* (2022) A near-complete assembly of an Arabidopsis thaliana genome. Mol. Plant 15: 1247-1250.
6. Xu, M., Du, Q., Tian, C., Wang, Y.* and Jiao, Y.* (2021) Stochastic gene expression drives mesophyll protoplast regeneration. Sci. Adv. 7: abg8466.
7. Zhao, F., Du, F., Oliveri, H., Zhou, L., Ali, O., Chen, W., Feng, S., Wang, Q., Lü, S., Long, M., Schneider, R., Sampathkumar, A., Godin, C., Traas, J.* and Jiao, Y.* (2020) Microtubule-mediated wall anisotropy contributes to leaf blade flattening. Curr. Biol. 30: 3972-3985.
Highlighted with a Dispatch article in Curr. Biol. 30: R1268-R1270
8. Zhou, Y., Zhao, X., Li, Y., Xu, J., Bi, A., Kang, L., Chen, H., Wang, Y., Wang, Y., Liu, S., Jiao, C., Lu, H., Wang, J., Yin, C., Jiao, Y.* and Lu, F.* (2020) Convergence within divergence: insights of wheat adaptation from Triticum population sequencing. Nat. Genet. 52: 1412-1422.
9. Cao, X., Wang, J., Xiong, Y., Yang, H., Yang, M., Ye, P., Bencivenga, S., Sablowski, S. and Jiao, Y.* (2020) A self-activation loop maintains meristematic cell fate for branching. Curr. Biol. 30: 1893-1904.
10. Tian, C., Wang, Y., Yu, H., He, J., Shi, B., Du, Q., Provart, N.J., Meyerowitz, E.M., and Jiao, Y.* (2019) A gene-expression map of shoot domains reveals new regulatory mechanisms. Nat. Commun. 10: 141.
11. Shi, B., Guo, X., Wang, Y., Xiong, Y., Wang, J., Hayashi, K.-i., Lei, J., Zhang, L.* and Jiao, Y.* (2018) Feedback from lateral organs controls shoot apical meristem growth by modulating auxin transport. Dev. Cell 44: 204-216.
12. Guan, C., Wu, B., Yu, T., Wang, Q., Krogan, N.T., Liu, X. and Jiao, Y.* (2017) Spatial auxin signaling controls leaf flattening in Arabidopsis. Curr. Biol. 27: 2940-2950.
Selected for F1000 Prime
13. Qi, J., Wu, B., Feng, S., Lü, S., Guan, C., Zhang, X., Qiu, D., Hu, Y., Zhou, Y., Li, C., Long, M.* and Jiao, Y.* (2017) Mechanical regulation of organ asymmetry in leaves. Nat. Plants 3: 724-733.
Featured on the cover
14. Wang, J., Tian, C., Zhang, C., Shi, B., Cao, X., Zhang, T.-Q., Zhao, Z., Wang, J.-W. and Jiao, Y.* (2017) Cytokinin signaling activates WUSCHEL expression during axillary meristem initiation. Plant Cell 29: 1374-1387.
Featured on the cover
Highlighted with a Spotlight article in Trends Plant Sci 22: 815-817
完整论文列表：http://jiaolab.genetics.ac.cn/publication.html
