研究方向
1） 发育与衰老的系统生物学
2） 调控网络的计算推理
3） 图像分析、数据集成和网络分析的计算算法开发
代表性论文
1. Jiawei Chen^, Hao Xu^, Wanyu Tao, Zhaoxiong Chen, Yuxuan Zhao and Jing-Dong J. Han*. Transformer for one stop interpretable cell type annotation. Nature Communications, Jan 2023.
2. Xiaoli Zhang^, Quanlong Jiang^, Jiyang Li^, Shiqiang Zhang^, Yaqiang Cao, Xian Xia, Donghong Cai, Jiaqi Tan, Jiekai Chen and Jing-Dong J. Han*. KCNQ1OT1 promotes genome-wide transposon repression by guiding RNA–DNA triplexes and HP1 binding. Nature Cell Biology, Oct 2022.
3. Dawei Shi^, Xian Xia^, Aoyuan Cui^, Zhongxiang Xiong, Yizhen Yan, Jing Luo, Guoyu Chen, Yingying Zeng, Donghong Cai, Lei Hou, Joseph McDermott, Yu Li, Hong Zhang and Jing-Dong J. Han*. The precursor of PI(3,4,5)P3 alleviates aging by activating daf-18(Pten) and independent of daf-16. Nature Communications Sep, 2020.
4. Xian Xia^, Xingwei Chen^, Gang Wu, Fang Li, Yiyang Wang, Yang Chen, Mingxu Chen, Xinyu Wang, Weiyang Chen, Bo Xian, Weizhong Chen, Yaqiang Cao, Chi Xu, Wenxuan Gong, Guoyu Chen, Donghong Cai, Wenxin Wei, Yizhen Yan, Kangping Liu, Nan Qiao, Xiaohui Zhao, Jin Jia, Wei Wang, Brian K. Kennedy, Kang Zhang, Carlo V. Cannistraci, Yong Zhou* and Jing-Dong J. Han*. Three-dimensional facial-image analysis to predict heterogeneity of the human ageing rate and the impact of lifestyle. Nature Metabolism Sep, 2020.
5. Xiaoyang Dou^, Jerome Boyd-Kirkup^, Joseph McDermott^, Xiaoli Zhang^, Fang Li, Bowen Rong, Rui Zhang, Bisi Miao, Peilin Chen, Hao Cheng, Jianhuang Xue, David Bennett, Jiemin Wong, Fei Lan and Jing-Dong J. Han*. The strand-biased mitochondrial DNA methylome and its regulation by DNMT3A. Genome Research September, 2019.
6. Hao Cheng^, Hongwen Xuan^, Christopher D. Green, Yixing Han, Na Sun, Hongjie Shen, Joseph McDermott, David Bennett, Fei Lan and Jing-Dong J. Han*. Repression of human and mouse brain inflammaging transcriptome by broad gene-body histone hyperacetylation. PNAS.July, 2018.
7. Na Sun^, Xiaoming Yu^, Fang Li^, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green, Joseph McDermott, Qin Shen, Naihe Jing & Jing-Dong J. Han*. Inference of differentiation time for single cell transcriptomes using cell population reference data. Nature Communications. November, 2017.
8. Lei Hou^, Dan Wang^, Di Chen^, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, William B. Mair, Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, March 8, 2016.
9. Weiyang Chen,Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J Han*. Three-dimensional human facial morphologies as robust aging markers. Cell Research. April, 2015.
