研究方向
关注“细胞建筑学”：各个亚细胞结构是如何搭建成一个具有完整生物学功能的细胞，以及“生物大分子社会学”：细胞内的细胞器、生物大分子之间的相互关系。
我们主要研究方向包括：
• 在纳米、亚纳米尺度对基础细胞生物学问题的研究。
• 对包括神经退行性疾病在内的老龄化疾病致病机制的研究。
• 适用于组织样品的高分辨原位结构生物学方法优化。
代表性论文
(1). Li, Z., Du, W., Yang, J., Lai, D.-H., Lun, Z.-R., Guo, Q.#, 2023. Cryo-Electron Tomography of Toxoplasma gondii Indicates That the Conoid Fiber May Be Derived from Microtubules. Advanced Science n/a, 2206595. (#Corresponding author)
(2). Li, W., Lu, J., Xiao, K., Zhou, M., Li, Y., Zhang, X., Li, Z., Gu, L., Xu, X., Guo, Q.#, Xu, T.#, Ji, W.#, (2023). Integrated multimodality microscope for accurate and efficient target-guided cryo-lamellae preparation. Nature Methods 20, 268-275. (#Corresponding author)
(3). Jiang, W., Wagner, J., Du, W., Plitzko, J., Baumeister, W., Beck, F.#, and Guo, Q.# (2022). A transformation clustering algorithm and its application in polyribosomes structural profiling. Nucleic Acids Research 50, 9001-9011. (#Corresponding author)
(4). Guo, Q., Bin, H., Cheng, J., Seefelder, M., Engler, T., Pfeifer, G., Oeckl, P., Otto, M., Moser, F., Maurer, M., Pautsch, A., Baumeister, W., Fernandez-Busnadiego, R., Kochanek, S. (2018). The cryo-electron microscopy structure of huntingtin. Nature 555, 117–120.
(5). Guo, Q., Lehmer, C., Martinez-Sanchez, A., Rudack, T., Beck, F., Hartmann, H., Hipp, M.S., Hartl, F.U., Edbauer, D., Baumeister, W., Fernandez-Busnadiego, R. (2018) In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment. Cell 172, 696-705.e612.
