研究方向:
1. 小分子诱导细胞重编程的分子机制研究
2. 心血管系统和代谢系统相关功能细胞（例如心肌细胞、肝脏细胞等）的直接重编程和原位再生
3. 逆转组织器官纤维化及诱导组织器官原位再生的小分子药物开发
代表性科研论文：
1. Zhao Y*, #, Zhao T #, Guan JY #, Zhang X #, Fu Y #, Ye JQ #, Zhu JL, Meng GF, Ge J, Yang SS, Cheng L, Du YQ, Zhao CR, Wang T, Su LL, Yang WF, Deng HK* A XEN-like state bridges the cell fate transition of fibroblasts to pluripotency during chemical reprogramming. Cell. 2015. 17;163(7):1678-91.
2. Hou PP #, Li YQ #, Zhang X #, Liu C #, Guan JY #, Li HG #, Zhao T, Ye JQ, Yang WF, Liu K, Ge J, Xu J, Zhang Q, Zhao Y*, Deng HK* Pluripotent Stem Cells Induced from Mouse Somatic Cells by Small-Molecule Compounds. Science, 2013. 341(6146): p. 651-654.
3. Li X #, Zuo XH #, Jing JZ #, Ma YT, Wang JM, Liu DF, Zhu JL, Du XM, Xiong L, Du YY, Xu J, Xiao X, Wang JL, Chai Z*, Zhao, Y*, Deng HK* Small-Molecule-Driven Direct Reprogramming of Mouse Fibroblasts into Functional Neurons. Cell Stem Cell. 2015. 17(2): p. 195-203.
4. Ye J #, Ge J #, Zhang X #, Cheng L, Zhang ZY, He S, Wang Y, Lin H, Yang WF, Liu JF, Zhao Y*, Deng HK* Pluripotent stem cells induced from mouse neural stem cells and small intestinal epithelial cells by small molecule compounds. Cell Research. 2016. 26(1):34-45.
5. Shu J #, Wu C #, Wu YT #, Li ZY #, Shao SD, Zhao WH, Tang X, Yang H, Shen LJ , Zuo XH, Yang WF, Shi Y, Chi XC, Zhang HQ, Gao G, Shu YM, Yuan KH , He WW, Tang C*, Zhao Y, Deng HK* Induction of Pluripotency in Mouse Somatic Cells with Lineage Specifiers. Cell, 2013. 153(5): p. 963-975.
6. Zhao Y #, Yin XL #, Qin H #, Zhu FF, Liu HS, Yang WF, Zhang Q, Xiang CA, Hou PP, Song ZH, Liu YX, Yong J, Zhang PB, Cai J, Liu M, Li HG, Li YQ, Qu XX, Cui K, Zhang WQ, Xiang TT, Wu YT, Zhao YD, Liu C, Yu C, Yuan KH, Lou JN, Ding MX, Deng HK. TwoSupporting Factors Greatly Improve the Efficiency of Human iPSC Generation. Cell Stem Cell, 2008. 3(5): p. 475-479.
7. Cai J #, Zhao Y #, Liu YX #, Ye F, Song ZH, Qin H, Meng S, Chen YZ, Zhou RD, Song XJ, Guo YS, Ding MX, Deng HK. Directeddifferentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007. 45(5): p. 1229-1239.
8. Li YQ #, Zhang QA #, Yin XL, Yang WF, Du YY, Hou PP, Ge J, Liu C, Zhang WQ, Zhang X, Wu YT, Li HG, Liu K, Wu C, Song ZH, Zhao Y*, Shi Y*, Deng HK* Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research, 2011. 21(1): p. 196-204.
