研究方向
着重发展基因组编辑技术，特别是其在高通量功能基因组学方面的技术平台建设，用于基因、非编码RNA以及多种基因组调控元件的功能研究；同时结合表观修饰识别、动态成像等手段，研究癌症、感染等重大疾病发生发展的分子机制，为发展高效治疗手段提供新的药物靶点和思路。
代表性论文
1. Qu L, et al. (2022) Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants. Cell 185, 1728-1744 e1716.
2. Yi Z, et al. (2022) Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo. Nature Biotechnology 40(6): 946-955.
3. Xu P, et al. (2021) Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature Biotechnology 39(11), 1403–1413.
4. Qu L, et al. (2019) Programmable RNA editing by recruiting endogenous ADAR using engineered RNAs. Nature Biotechnology 37, 1059-1069.
5. Zhao X, et al. (2019) Human neonatal Fc receptor is the cellular uncoating receptor for enterovirus B. Cell 177, 1-13.
6. Liu Y, et al. (2018) Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites. Nature Biotechnology 36, 1203-1210.
7. Zhu S, et al. (2016) Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR library. Nature Biotechnology 34, 1279-1286.
8. Zhou Y, et al. (2014) High-throughput Screening of a CRISPR/Cas Library for Functional Genomics in Human Cells. Nature 509, 487-91.
9. Yang J, et al. (2014) Complete Decoding of DNA Recognition by TAL Effector RVDs. Cell Res. 24:628-631.
