研究方向：刘颖教授从事细胞应激和稳态调控的研究，主要关注于细胞对线粒体胁迫和氨基酸匮乏的感知和响应机制。这些过程的失衡与癌症和代谢疾病密切相关，也是衰老的重要诱因。现为北大-清华生命科学联合中心、北京市未来基因诊断高精尖创新中心研究员，新基石研究员。曾入选美国霍华德休斯医学研究所(HHMI)国际研究学者、国家杰青、科技创新领军人才，获科学探索奖、中国青年女科学家奖、谈家桢生命科学创新奖等。
代表性科研论文：
1. Yan G, Yang J, Li W, Guo A, Guan J and Liu Y*, Genome-wide CRISPR screens identify ILF3 as a mediator of mTORC1-dependent amino acid sensing. Nature Cell Biology (2023).
2. Wang D#, Xu C#, Yang W, Chen J, Ou Y, Guan Y, Guan J, Liu Y*; E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression. Molecular Cell 82, 709-712 (2022).
3. Xia P, Zhou L, Guan J, Ding W, Liu Y*; Splicing factor PRP-19 regulates mitochondrial stress response. Life Metabolism 1, 81-93 (2022).
4. Chen J#*, Ou Y#, Luo R, Wang J, Wang D, Guan J, Li Y, Xia P, Chen P, Liu Y*. SAR1B senses leucine levels to regulate mTORC1 signalling. Nature 596(7871), 281-284(2021).
5. Li Y, Ding W, Li C-Y and Liu Y*. HLH-11 modulates lipid metabolism in response to nutrient availability. Nature Communications 11, 5959 (2020).
6. Liu Y*. Epigenetic codes of mitochondrial homeostasis. Nature Aging 1,153-154 (2021).
7. Shao L-W#, Peng Q#, Dong M, Gao K, Li YM, Li Y, Li C-Y* and Liu Y*. Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity. Nature Communications 11, 4639 (2020).
8. Gao K, Li Y, Hu SM and Liu Y*. SUMO peptidase ULP-4 regulates mitochondrial UPR-mediated innate immunity and lifespan extension. eLife 8, e41792 (2019).
9. Ma C, Niu R, Huang T, Shao LW, Peng Y, Ding W, Wang Y, Jia G, He C, Li CY, He A and Liu Y*. N6-methyldeoxyadenine is a transgenerational epigenetic signal for mitochondrial stress adaptation. Nature Cell Biology 21(3), 319-327 (2019).
10. Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y and Liu Y*. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature 557, 585-589 (2018).
11. Chen J#, Ou Y#, Li Y, Hu S, Shao LW and Liu Y*. Metformin extends C. elegans lifespan through lysosomal pathway. eLife 6, e31268 (2017).
12. Shao LW, Niu R and Liu Y*. Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response. Cell Res. 11, 1182-1196 (2016). (cover story)
13. Liu Y, Samuel BS, Breen PC and Ruvkun G*. Caenorhabditis elegans pathways that surveil and defend mitochondria. Nature 508, 406–410 (2014).
14. Liu Y, Tan H, Tian H, Liang C, Chen S and Liu Q. Autoantigen La promotes efficient RNAi, antiviral response and transposon silencing by facilitating multiple-turnover RISC catalysis. Mol. Cell 44, 502-508 (2011).
15. Liu Y, Ye X, Jiang F, Liang C, Chen D, Peng J, Kinch L, Grishin N, Liu Q. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 5941, 750-753 (2009).
