研究方向
放射化学生物学（Radiochemical Biology）
PET影像开辟了在分子层面上进行疾病诊断的新思路，它是精准医疗的排头兵。 近来，PET分子影像已成为了我国各大医院的常规检查项目，市场份额在2015年超过了100亿元。与X射线、CT及MRI等传统临床影像不同， PET影像的诊断效果依赖于放射性标记的分子探针。但是，由于放射化学的特殊性以及多学科融合的复杂性，我国在PET分子探针上的基础研究还相对落后，与国际先进水平差距巨大。即使是国内顶尖的医疗机构，也不得不从国外引进PET探针，辅助国内的临床研究。回国之后，我们计划在北大化院、北大-清华生命联合中心以及周边医学院所的支持下，搭建起我国第一个立足基础研究的PET分子影像平台，填补国内空白，切实推动我国精准医疗事业的发展。
主要的研究方向如下：
1. PET分子影像引导的活体蛋白激活及药物释放；
2. 外源放疗及内源核素衰变激活的活体蛋白激活及药物释放；
3. 含硼PET分子影像探针及硼中子捕获治疗药物的研究与临床应用;
4. 新型医用核素的加速器生产研究与临床应用。
代表性论文
1. Dongban Duan, Hui Liu, Mengxin Xu, Mengqi Chen, Yuxiang Han, Yaxin Shi, Zhibo Liu* Size-Controlled Synthesis of Drug Loaded Zeolitic Imidazolate Framework in Aqueous Solution and Size Impact on Their Cancer Theranostics In Vivo. ACS Appl. Mater. Interfaces., 2018, 10 (49), 42165-42174
2. Yaxin Shi, Jiyuan Li, Zizhu Zhang, Dongban Duan, Zhengchu Zhang, Hui Liu, Tong Liu, Zhibo Liu*, Tracing Boron with Fluorescence and PET Imaging of Boronated Porphyrin Nanocomplex for Imaging Guided Boron Neutron Capture Therapy. ACS Appl. Mater. Interfaces., 2018, 10 (50), 43387-43395
3. Mengxin Xu, Yuxiang Han, Guizhong Liu, Yang Xu, Dongban Duan, Hui Liu, Felix Du, Peter Luo, Zhibo Liu*, Preclinical Study of A Fully Human Anti-PD-L1 Antibody as A Theranostic Agent for Cancer Immunotherapy. Mol Pharm. 2018, 15(10): 4426-4433.
4. Dongban Duan, Hui Liu, Yang Xu, Yuxiang Han, Mengxin Xu, Zhengchu Zhang, Zhibo Liu*. Activating TiO2 Nanoparticle: Gallium-68 Serves As A High-Yielded Photon Emitter for Cerenkov Induced Photodynamic Therapy. ACS Appl. Mater. Interfaces. 2018, 10 (6), 5278–5286
5. Hui Liu, Yuxiang Han, Jiyuan Li, Ming Qin, Qunfeng Fu, Chunhong Wang, Zhibo Liu*. A 18F-labeled Alanine Derivative Serve as An ASCT2 Marker for Cancer Imaging. Mol Pharm., 2018, 15 (3), 947-954
6. Zhibo Liu*, Kuo-Shyan Lin, François Bénard, Dale O. Kiesewetter, David M. Perrin*, Xiaoyuan Chen* (2015) A Broadly Applicable One-step 18F-Labeling Protocol with Organotrifluoroborates. Nat. Protoc. 10: 1423–1432. (co-corresponding author).
7. Zhibo Liu*, Haojun Chen, Kai Chen, Yihan Shao, Dale O. Kiesewetter, Gang Niu, Xiaoyuan Chen* (2015) Boramino Acid as A Marker for Amino Acid Transporter. Science Advances 1: e1500694. (co-corresponding author, highlighted on C&EN News)
8. Zhibo Liu, Maral Pourghiasian, Gemma Dias, Joseph Lau, Francois Benard, Kuo-shyan Lin, David M. Perrin (2014) An Organotrifluoroborate for Broadly Applicable One-Step 18F-Labeling, Angew. Chem. Int. Ed. 53: 11876–11880. (Cover feature, highlighted on C&EN News)
