研究方向
天然免疫赋予机体对病原及肿瘤细胞的抵抗力，是人类抵抗感染与肿瘤的第一道防线。天然免疫失调引起各种感染性疾病、自身免疫病和肿瘤。尤其重要的是，识别细胞内DNA的cGAS-STING通路，对肿瘤的免疫监视及免疫治疗都至关重要。蒋争凡实验室是世界上同期发现STING蛋白的三个实验室之一，对其生理学功能进行了深入系统的研究。发现ERIS的二聚体化对其激活天然免疫反应重要；细胞通过STING-TBK1活化STAT6及NF-kB在cGAS-STING通路中的重要作用；发现特异性降解3'3'-cGAMP的磷酸二酯酶；发现多种Caspase负调控天然免疫反应，避免过度的免疫反应及凋亡细胞保持“免疫沉默”的机制；发现锰元素在cGAS-STING通路中发挥“警报素”与“激动剂”的双重功能，以此为基础发现锰离子的免疫调节功能，为锰元素在体内的生理学功能，特别是作为免疫调节剂的功能研究打开了一个新的窗口，并揭示锰元素未来在抗感染、抗肿瘤及免疫佐剂等应用方面拥有广阔的前景。
代表性科研论文
1) Ning X, Wang Y, Jing M, Sha M, Lv M, Gao P, Zhang R, Huang X, Feng J, Jiang Z*. 2019, Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS and IRF3. Molecular Cell, 74: 1-13.
2) Wang C, Guan Y, Lv M, Zhang R, Guo Z, Wei X, Du X, Yang J, Li T, Wan Y, Su X, Huang X, Jiang Z*. 2018, Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-stranded DNA and Is Required for the Host Defense against DNA Viruses. Immunity, 48: 675-687.
3) Wang Y, Ning X, Gao P, Wu S, Sha M, Lv M, Zhou X, Gao J, Fang R, Meng G, Su X, Jiang Z*. 2017, Inflammasome activation triggers caspases-mediated cleavage of cGAS to regulate responses to DNA virus infection. Immunity, 46: 393-404.
4) Fang R, Jiang Q, Zhou X, Wang C, Guan Y, Tao J, Xi J, Feng J, Jiang Z*. 2017, MAVS activates TBK1 and IKKε through TRAFs in NEMO dependent and independent manner. PLoS Pathogens, 13: e1006720. doi: 10.1371/journal. ppat.1006720.
5) Gao J, Tao J, Liang W, Zhao M, Du X, Cui S, Duan H, Kan B, Su X, Jiang Z*. 2015, Identification and characterization of phosphodiesterase V-cGAPs that specifically degrade 3’3’-cyclic GMP-AMP. Cell Research. 25: 539-550.
6) Chen H, Sun H, You F, Sun W, Zhou X, Chen L, Yang J, Wang Y, Tang H, Guan Y, Xia W, Gu J, Ishikawa H, Gutman D, Barber G, Qin Z, Jiang Z*. 2011, Activation of STAT6 by STING is Critical for Antiviral Innate Immunity. Cell. 147: 436-446.
7) You FP, Sun H, Zhou X, Sun WX, Liang SM, Zhai ZH & Jiang Z*. 2009, PCBP2 mediates degradation of the adaptor MAVS via the HECT ubiquitin ligase AIP4. Nature Immunology. 10: 1300-1308.
8) Sun W, Li Y, Chen L, Chen H, You F, Zhou X, Zhou Y, Zhai Z, Chen D, Jiang Z*. 2009, ERIS, an ER IFN stimulator, activates innate immune signaling through dimerization. Proc Natl Acad Sci USA. 106: 8653-8.
