报告人: Prof. Xiaobo Zhou
Carl Vartian Distinguished Professor
Director of Center for Computational Systems Medicine
School of Biomedical Informatics, Medical School, and School of Dentistry
The University of Texas Health Science Center at Houston GSBS Program, MD Anderson Cancer Center and UT Health Houston, USA
时间: 2018年4月19日(星期四) 15:40 ~ 16:30
地点: 北京大学综合科研楼137会议室
简介:
Xiaobo Zhou, Ph.D., is currently a Carl Vartian Distinguished Professor and the Director of Center for Computational Systems Medicine, at School of Biomedical Informatics, McGovern Medical School, and School of Dentistry, University of Texas Health Sciences Center at Houston. He received PhD from Beijing University, Beijing, China, in 1998, in applied mathematics. From 1998 to 2004, he was a Postdoctoral Fellow with Tsinghua University, Beijing; University of Missouri-Columbia; Texas A&M University, College Station; and Harvard Medical School, Boston, MA. From 2005 to 2007, he was a faculty with Brigham and Women’s Hospital and Harvard University, Boston, MA. From 2007 to 2012, he was the Chief of Bioinformatics, Professor of Radiology, The Methodist Hospital, Houston, TX, and Cornell Medical College, NY. From 2013 to 2017, he has been the Professor, serving the Chief of Bioinformatics, Director of Center for Bioinformatics and Systems Biology in Wake Forest University School of medicine. Currently he is still an Adjunct Professor at Wake Forest University School of Medicine.
Dr. Zhou has been working on data sciences and Bioinformatics area for over 20 years. He is an expert in Bioinformatics, Systems Biology, Imaging Informatics and Clinical Informatics. He has both dry lab and wet lab. Dr. Zhou and his colleagues pioneered the imaging aided surgical design and medical device optimization, computational genomics, high-content cellular imaging informatics, multi-scale systems biology guiding cancer and regenerative medicine, and phosphor-proteomics data analysis. He has published about 250 peer-reviewed research articles including Science, Nature series, various IEEE Transactions, Cancer Research, Nucleic Acids Research, Biomaterials, Bioinformatics, Plos Computational Biology, etc., and also authorized two books. Dr. Zhou has been fully funded by NIH since 2005. As a PI, he currently has five R01s and two U01s ongoing. He was also the co-PI of the NIH U54 Center for Systems Modeling of Cancer Development, the site PI of the PCORI CDRN project - Scalable Collaborative Infrastructure for a Learning Health Systems, the Director of Biomedical Informatics Program of NIH U54 Wake Forest CTSA center grant, and the Director of Cancer Bioinformatics at Wake Forest University Comprehensive Cancer Center NIH P30.
Abstract:
Engineering vascularized bone tissue for scaffolding and repairing remains a significant clinical problem. We are developing systems biology approaches to optimizing the temporal combinations of growth factor release from the engineering vessel grafted 3D scaffolds for in-vivo Bone regeneration (sBone system). 1) Using the classical BMP2/IGF1 dual-growth-factor temporal combination system as the biological model, our systems biology research, supported by coordinated experiments and multi-scale bio-assay and high-throughput screening, demonstrated the induction of Smad1/2 signaling pathways of MSCs by BMP2, which gradually remodels the expression pattern of Runx2 and Osx pathways, and thus sensitizes MSCs to the late IGF1 cue. We also engineered the BMP2/IGF1 dual controlled release bone scaffolds and proved the hypothesis remains valid for the bone regeneration in 3D macro-porous β-calcium phosphate (TCP) scaffolds. 2) To address the challenge of vascularization, we used a unique electrochemical cell detachment technique (EDT) to rapidly engineer a capillary-like vessel by detaching a human umbilical vein endothelial cell (HUVEC) layer from a solid rod to generate a hollow lumen with structural integrity, and transferred it to a centrally channeled, macro- porous VEGF-releasing TCP scaffold. 3) We recently have developed novel 3D multi-scale system models to study the effects of temporal combination of growth factors controlled by the gelatin micro-beads releasing system and the vascularization events from the pre-embedded HUVEC central channels of macro-porous TCP scaffolds and the effects on bone regeneration. Our preliminary studies indicate that the 3D multi-scale models can be potentially applied to predict vascularized bone regeneration with specific growth factor combinations and scaffold designs. At the end of this talk, I will also briefly talk about the application of systems biology approach to cancer immune research.
