生命科学联合中心
学术报告
题目：DNA Mismatch Repair in Cancer Susceptibility and Therapy.
报告人：Guo-Min Li, Ph.D.
Professor of Biochemistry
University of Southern California Keck School of Medicine
时间：2016-4-14（周四），13:00-14:00pm
地点：北京大学老化学楼东配楼101报告厅
联系人：孔道春 北大-清华生命科学联合中心
DNA mismatch repair (MMR) is an important genome maintenance system that ensures replication fidelity by specifically removing misincorporated nucleotides in the newly synthesized DNA strand during DNA replication. Defects in MMR genes lead to a mutator phenotype and are the genetic basis of many types of hereditary and sporadic human cancers. However, not all cancers displaying a classical MMR deficient phenotype have identifiable mutations in MMR genes, suggesting a novel mechanism responsible for this subset of cancer. In this presentation, I will discuss our recent discoveries that MMR function is regulated by posttranslational modifications, including histone methylation and phosphorylation of MMR proteins, and how we could use these discoveries in cancer diagnosis and therapy.
主讲人简介：
Dr. Guo-Min Li studies genome instability and cancer, with a focus on DNA mismatch repair (MMR), an important cellular pathway that ensures replication fidelity by correcting mispairs created during DNA replication. Dr. Li has made seminal contributions to the field, including discovering MMR defects in colorectal tumors displaying microsatellite instability (MSI), identifying and characterizing the majority of human MMR components, reconstituting the human MMR reaction in vitro, and identifying the apoptotic function of MMR.
