研究方向
白洋实验室致力于研究微生物组与宿主的良性互作机制，重点关注非模式微生物。这些非模式微生物在微生物组中占据绝大多数，与宿主形成良性互作关系，对宿主的生长与健康至关重要。然而，我们对他们的了解非常有限。实验室的研究方向主要包括：
一、运用微生物组学数据分析、微生物高通量培养和分子遗传学技术，探索根际微生物组对水稻、拟南芥等植物生长与健康所起的作用，以及其潜在的分子机制。
二、基于微生物基因组和宏基因组资源，高效挖掘微生物中尚未被发现的暗物质，探索全新的生物学过程及其在实际应用中的潜力。
三、结合微生物分子遗传学和生物信息学等方法，开发推动微生物组领域发展的关键技术。
代表性科研论文
1. Shouyue Zhang#, Ao Sun#, Jing-Mei Qian#, Shuo Lin#, Wenjing Xing, Yun Yang, Han-Zhou Zhu, Xin-Yi Zhou, Yan-Shuo Guo, Yun Liu, Yu Meng, Shu-Lin Jin, Wenhao Song, Cheng-Ping Li, Zhaofu Li1, Shuai Jin, Jian-Hua Wang, Meng-Qiu Dong, Caixia Gao, Chunlai Chen*, Yang Bai*, Jun-Jie Gogo Liu*. (2024). Pro-CRISPR PcrIIC1 associated Cas9 system for enhanced bacterial immunity. Nature, in press.
2. Jingying Zhang, Weidong Liu, Jingshu Bu, Yanbing Lin, Yang Bai*. (2023). Host genetics regulate the plant microbiome. Current Opinion in Microbiology, 72:102268.
3. Sunde Xu#, Yong-Xin Liu#, Tomislav Cernava#, Hongkai Wang, Yaqi Zhou, Tie Xia, Shugeng Cao, Gabriele Berg, Xing-Xing Shen, Ziyue Wen, Chunshun Li, Baoyuan Qu, Hefei Ruan, Yunrong Chai, Xueping Zhou, Zhonghua Ma, Yan Shi, Yunlong Yu*, Yang Bai*, Yun Chen*. (2022). Fusarium fruiting body microbiome member Pantoea agglomerans inhibits fungal pathogenesis by targeting lipid rafts. Nature Microbiology, 7: 831–843.
4. Bo Bai, Weidong Liu, Xingyu Qiu, Jie Zhang, Jingying Zhang*, Yang Bai*. (2022). The root microbiome: Community assembly and its contributions to plant fitness. Journal of Integrative Plant Biology, 64: 230–243.
5. Jingying Zhang#, Yong-Xin Liu#, Xiaoxuan Guo, Yuan Qin, Ruben Garrido-Oter*, Paul Schulze-Lefert*, Yang Bai*. (2021). High-throughput cultivation and identification of bacteria from the plant root microbiota. Nature Protocols, 16: 988–1012.
6. Yong-Xin Liu#*, Yuan Qin#, Tong Chen#, Meiping Lu, Xubo Qian, Xiaoxuan Guo, Yang Bai*. (2021). A practical guide to amplicon and metagenomic analysis of microbiome data. Protein Cell, 12: 315–330.
7. Jingying Zhang#, Yong-Xin Liu#, Na Zhang#, Bin Hu#, Tao Jin#, Haoran Xu, Yuan Qin, Pengxu Yan, Xiaoning Zhang, Xiaoxuan Guo, Jing Hui, Shouyun Cao, Xin Wang, Chao Wang, Hui Wang, Baoyuan Qu, Guangyi Fan, Lixing Yuan, Ruben Garrido-Oter, Chengcai Chu*, Yang Bai*. (2019). NRT1.1B is associated with root microbiota composition and nitrogen use in field-grown rice. Nature Biotechnology, 37: 676–684.
8. Ancheng C. Huang#, Ting Jiang#, Yong-Xin Liu, Yue-Chen Bai, James Reed, Baoyuan Qu, Alain Goossens, Hans-Wilhelm Nützmann, Yang Bai*, Anne Osbourn*. (2019). A specialized metabolic network selectively modulates Arabidopsis root microbiota. Science, 364: eaau6389.
9. Yong-Xin Liu, Yuan Qin, Yang Bai*. (2019). Reductionist synthetic community approaches in root microbiome research. Current Opinion in Microbiology, 49: 97–102.
10. Qingwen Chen#, Ting Jiang#, Yong-Xin Liu, Haili Liu, Tao Zhao, Zhixi Liu, Xiaochao Gan, Asis Hallab, Xuemei Wang, Juan He, Yihua Ma, Fengxia Zhang, Tao Jin, M.Eric Schranz, Yong Wang, Yang Bai*, Guodong Wang*. (2019). Recently duplicated sesterterpene (C25) gene clusters in Arabidopsis thaliana modulate root microbiota. Science China Life Sciences, 62: 947–958.
11. Jingying Zhang#, Na Zhang#, Yong-Xin Liu#, Xiaoning Zhang, Bin Hu, Yuan Qin, Haoran Xu, Hui Wang, Xiaoxuan Guo, Jingmei Qian, Wei Wang, Pengfan Zhang, Tao Jin*, Chengcai Chu*, Yang Bai*. (2018). Root microbiota shift in rice correlates with resident time in the field and developmental stage. Science China Life Sciences, 61: 613–621.
12. Yang Bai#, Daniel Müller#, Girish Srinivas#, Ruben Garrido-Oter#, Eva Potthoff, Matthias Rott, Nina Dombrowski, Philipp Münch, Stijn Spaepen, Mitja Remus-Emsermann, Bruno Hüttel, Alice McHardy, Julia Vorholt*, Paul Schulze-Lefert*. (2015). Functional overlap of the Arabidopsis leaf and root microbiota. Nature, 528: 364–369.
