研究方向
发展生物磁共振技术，发展顺磁核磁探针计算和相应算法，表征生物大分子的动态结构、动态相互作用; 发展质谱交联数据的定量优化方法，发展整合生物物理化学方法，表征非平衡态下的生物大分子的结构动态; 探究化学修饰和物理环境因素对生物大分子结构动态的影响，重点关注泛素的磷酸化和甲基化对蛋白质、RNA构象的调控。
代表性论文
§ Ma Y, Li H, Gong Z, Yang S, Wang P, Tang C (2022) Nucleobase clustering contributes to the formation and hollowing of repeat-expansion RNA condensate. J Am Chem Soc, 144:4716–4720
§ Dong X, Qin LY, Gong Z, Qin Q, Zhou HX, Tang C (2022) Preferential interactions of a crowder protein with the specific binding site of a native protein complex. J Phys Chem. Lett,13:792–800
§ Gong Z, Ye SX, Tang C. (2020) Tightening the crosslinking distance restraints for better resolution of protein structure and dynamics. Structure, 28:1160-1167
§ Liu Z., Dong X., Yi HW, Yang J, Gong Z, Wang Y, Liu K, Zhang WP, Tang C (2019) Structural basis for the recognition of K48-linked Ub chain by proteasomal receptor Rpn13. Cell Discov 5, 19
§ Huang JB, Dong X, Gong Z, Qin LY, Yang S, Zhu YL, Wang X, Zhang DL, Zou TT, Yin P, Tang C. (2019) Solution structure of the RNA recognition domain of METTL3-METTL14 N6-methyladenosine methyltransferase. Protein Cell, 10:272-284
§ Gong Z, Charles DS, Tang C (2018) Theory and practice of using solvent paramagnetic relaxation enhancement to characterize protein conformational dynamics. Methods, 148:48-56
§ Dong X, Gong Z, Lu YB, Liu K, Qing LY, Ran ML, Zhang CL, Liu Z, Zhang WP, Tang C. (2017). Ubiquitin S65 phosphorylation engenders a pH-sensitive conformational switch. Proc Natl Acad Sci USA, 114:6770-6775
§ Gong Z, Gu XH, Guo DC, Wang J, Tang C. (2017). Protein structural ensembles visualized by solvent paramagnetic relaxation enhancement. Angew Chem Int Ed, 56:1002-1006
