研究方向:
周岳实验室致力于研究表观遗传调控在植物发育和植物对环境的响应中的作用，通过跨学科的研究方法，利用遗传学、基因组学、细胞生物学和生物化学等研究手段，重点研究植物染色体3D结构的分子机理以及生物学功能。主要研究结果以第一作者发表在Nature Genetics，Genome Biology, PNAS，Plant Cell等刊物上。回到北大后，以通讯作者在Nature Communications, Plant Cell发表文章，揭示了植物染色体一级以及3D结构的调控模式。
代表性科研论文:
1. Yin, X., Romero-Campero, F JM, Yang, M., Baile, F., Cao, Y., Shu, J., Luo, L., Wang, D., Sun, S., Yan, P., Gong, Z., Mo, X., Qin, G., Calonje, M#., Zhou, Y#. Binding by the Polycomb complex component BMI1 and H2A monoubiquitination shape local and long-range interactions in the Arabidopsis genome. Plant Cell, doi: 10.1093/plcell/koad112.
2. Yang, T., Wang, D., Tian, G., Sun, L., Yang, M., Yin, X., Xiao, J., Sheng, Y., Zhu, D., He, H., Zhou, Y. Chromatin remodeling complexes regulate genome architecture in Arabidopsis. Plant Cell 34(7): 2638-2651, 2022.
3. Yin, X., Romero-Campero, F JM#., de Los Reyes, P., Yan, Peng., Yang, J., Tian, G., Yang, X., Mo, X., Zhao, S., Calonje, M#., Zhou, Y#. H2AK121ub in Arabidopsis associates with a less accessible chromatin state at transcriptional regulation hotspots. Nat Commum 12(1): 315, 2021.
回到北大前：
1. Zhou, Y., Wang, Y., Krause, K., Dogus, J., Zhang, Y., Turck, F. Telobox motifs recruit CLF/SWN-PRC2 for H3K27me3 deposition via TRB factors in Arabidopsis. Nat Genet 50(5):638-644, 2018.
2. Zhou, Y., Tergemina, E., Cui, H., Forderer, A., Hartwig, B., Velikkakam James, G., Schneeberger, K., and Turck, F. Ctf4-related protein recruits LHP1-PRC2 to maintain H3K27me3 levels in dividing cells in Arabidopsis thaliana. Proc Natl Acad Sci U S A 114, 4833-4838, 2017.
3. Zhou, Y*., Romero-Campero, F.J*., Gomez-Zambrano, A., Turck, F., and Calonje, M. H2A monoubiquitination in Arabidopsis thaliana is generally independent of LHP1 and PRC2 activity. Genome Biol 18, 69 2017.
4. Zhou, Y., Hartwig, B., James, G. V., Schneeberger, K. & Turck, F. Complementary Activities of TELOMERE REPEAT BINDING Proteins and Polycomb Group Complexes in Transcriptional Regulation of Target Genes. Plant Cell 28, 87-101, 2016.
