研究方向
汤超实验室主要进行系统生物学与物理生物学方面的研究。我们应用和发展定量方法和工具,有机地结合理论、计算和实验来提出和解决关键生物学问题,目的是发现生物世界中的基本规律及普适性原理。目前研究方向包括:细胞周期调控,细胞命运决定与转化,生物网络中的功能与拓扑结构的关系,发育与进化中的定量问题,细菌生长与代谢,生命现象中的非平衡热力学与统计物理问题,人工智能及在生物中的应用。
代表性论文
1. Li FT, Lu Y, Long T, Ouyang Q, Tang C, The yeast cell-cycle network is robustly designed, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 101, 4781, 2004.
2. Ma WZ, Trusina A, El-Samad H, Lim WA, Tang C, Defining network topology that can perform biochemical adaptation, CELL, 138, 760, 2009.
3. Chau AH, Walter JM, Gerardin J, Tang C, Lim WA, Designing synthetic regulatory networks capable of self-organizing cell polarization. CELL 151, 320, 2012.
4. Shu J, et al, Induction of pluripotency in mouse somatic cells with lineage specifiers, CELL, 153, 963, 2013.
5. Liu XL, Wang X, Yang XJ, Liu S, Jiang LL, Qu YM, Hu LF, Ouyang Q, Tang C, Reliable cell cycle commitment in budding yeast is ensured by signal integration, ELIFE: e03977, 2015.
6. Xiong L, Shi W, Tang C, Adaptation through proportion, PHYSICAL BIOLOGY, 13, 046007, 2016.
7. Shen J, Liu F, Petkova M, Tang C, Toward deciphering developmental patterning with deep neural network, bioRxiv, 374439 2018.
8. Wang X, Xia K, Yang X, Tang C, Growth strategy of microbes on mixed carbon sources, NATURE COMMUNICATIONS 10, 1279, 2019.