研究方向
2008年本科毕业于山东大学。2015年在中国科学院生物化学与细胞生物学研究所获博士学位，主要利用X-射线晶体学研究与内吞过程相关的小G蛋白Rab GTPases在膜泡运输过程中发挥功能的分子机制。2015年2月至2019年6月在美国洛克菲勒大学从事博士后研究，利用单颗粒冷冻电镜（single-particle Cryo-EM）技术对CFTR（Cystic Fibrosis Transmembrane conductance Regulator）蛋白发挥阴离子通道（anion channel）功能的分子机制进行了系统的阐释；并首次揭示了两种治疗囊性纤维化疾病（Cystic Fibrosis）的药物在该蛋白上的结合位点。2019年7月加入北京大学生命科学学院和生命科学联合中心，担任研究员，组建膜生物学与生物物理学实验室。
本课题组以结构生物学为主要手段，结合生物化学、细胞生物学和神经生物学等多种方法，研究生命过程中重要的膜蛋白—尤其是与重大疾病相关的膜蛋白—发挥功能的分子机制。目前涉及的膜蛋白主要为SLC（Solute Carrier）家族转运蛋白和RTK（Receptor Tyrosine Kinase）家族受体蛋白，关注的功能领域包括神经退行、癌症、程序性细胞死亡和免疫等。
代表性科研论文
At PKU:
-Representative papers
(*Co-first author, $ Corresponding author)
1. Xue Bai*, Pengyu Sun*, Xinghao Wang*, Changkun Long*, Shuyun Liao*, Song Dang, Shangshang Zhuang, Yongtao Du, Xinyi Zhang, Nan Li, Kangmin He$, and Zhe Zhang$; Structure and dynamics of the EGFR/HER2 heterodimer; Cell Discov.; 2023, 9(1): 18.
2. Yu Dang, Dong Zhou, Xiaojuan Du, Hongtu Zhao, Chia-Hsueh Lee, Jing Yang, Yijie Wang, Changdong Qin, Zhenxi Guo, and Zhe Zhang$; Molecular mechanism of substrate recognition by folate transporter SLC19A1; Cell Discov.; 2022, 8(1): 141.
3. Zelin Duan*, Xuezhen Lin*, Lixia Wang*, Qiuxin Zhen, Yuefeng Jiang, Chuxin Chen, Jing Yang, Chia-Hsueh Lee, Yan Qin, Ying Li, Bo Zhao$, Jianchuan Wang$, and Zhe Zhang$; Specificity of TGF-β1 signal designated by LRRC33 and integrin αVβ8; Nat. Commun.; 2022, 13(1):4988.
4. Zhaohan Lin, Yinglin Li, Yuqi Hang, Changhe Wang, Bing Liu, Jie Li, Lili Yin, Xiaohan Jiang, Xingyu Du, Zhongjun Qiao, Feipeng Zhu, Zhe Zhang$, Quanfeng Zhang$, and Zhuan Zhou$; Tuning the size of large dense-core vesicles and quantal neurotransmitter release via secretogranin II liquid-liquid phase separation; Adv. Sci.; 2022, e2202263.
5. Yuefeng Jiang, Tingting Liu, Chia-Hsueh Lee, Qing Chang, Jing Yang$, and Zhe Zhang$; The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1; Nature; 2020, 588(7839): 658-663.
-Others
1. Yansong Zhang, Siyuan Lin, Jingyu Peng, Xiaojuan Liang, Qi Yang, Xue Bai, Yajuan Li, Jinhua Li, Wei Dong, Yue Wang, Ying Huang, Yumeng Pei, Jiabao Guo, Wanni Zhao, Zhe Zhang, Min Liu$, and Alan Jian Zhu$; Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination; Mol. Cell; 2022, 82(8):1528-1542.
2. Yingdi Wang, Yiming Niu, Zhe Zhang, Kenneth Gable, Sita D Gupta, Niranjanakumari Somashekarappa, Gongshe Han, Hongtu Zhao, Alexander G Myasnikov, Ravi C Kalathur, Teresa M Dunn, and Chia-Hsueh Lee$; Structural insights into the regulation of human serine palmitoyltransferase complexes; Nat. Struct. Mol. Biol.; 2021, 28(3): 240-248.
Before PKU:
1. Fangyu Liu*, Zhe Zhang*, Anat Levit, Jesper Levring, Kouki K. Touhara, Brian K. Shoichet, and Jue Chen$; Structural identification of a hotspot on CFTR for potentiation; Science; 2019, 364(6446): 1184-1188.
2. Zhe Zhang*, Fangyu Liu*, and Jue Chen$; Molecular structure of the ATP-bound, phosphorylated human CFTR; Proc. Natl. Acad. Sci. USA; 2018, 115(50): 12757-12762.
3. Zhe Zhang* $, Balazs Tóth*, Andras Szollosi, Jue Chen, and Laszló Csanady$; Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation; eLife; 2018, 7: e36409.
4. Zhe Zhang, Fangyu Liu, and Jue Chen$; Conformational changes of CFTR upon phosphorylation and ATP binding; Cell; 2017, 170(3): 483-491.e8.
5. Fangyu Liu*, Zhe Zhang*, Laszló Csanady, David C Gadsby, and Jue Chen$; Molecular structure of the human CFTR ion channel; Cell; 2017, 169(1): 85-95.e8.
6. Zhe Zhang, and Jue Chen$; Atomic structure of the cystic fibrosis transmembrane conductance regulator; Cell; 2016, 167(6): 1586-1597.e9.
7. Zhe Zhang*, ShanshanWang*, Tong Shen, Jiangye Chen, and Jianping Ding$; Crystal structure of the Rab9A-RUTBC2 RBD complex reveals the molecular basis for the binding specificity of Rab9A with RUTBC2; Structure; 2014, 22(10): 1408-1422.
8. Zhe Zhang, Tianlong Zhang, Shanshan Wang, Zhou Gong, Chun Tang, Jiangye Chen, and Jianping Ding$; Molecular mechanism for Rabex-5 GEF activation by Rabaptin-5; eLife; 2014, 3: e02687.
