研究方向
高等植物有性生殖包括雌雄配子体形成、雌雄配子体相互作用、受精以及胚胎发生发育等生物学过程，这些过程受到严格的遗传调控。我们以双子叶模式植物拟南芥（Arabidopsis thaliana）为研究对象，研究高等植物有性生殖过程的分子调控机理，主要通过遗传学、生物化学和分子生物学的方法研究参与高等植物有性生殖过程调控的三大类主要因子，一是参与生殖过程调控的受体类激酶、多肽信号及其介导的信号传导；二是参与生殖过程调控的蛋白质降解和/或内膜运输途径中的重要调控因子；三是鉴定参与生殖过程调控的转录因子基因的功能。此外，我们还关注单子叶植物水稻中新的转基因技术的开发与完善。
代表性科研论文：
1. Zhong S., Li L., Wang Z., Ge Z., Li Q., Bleckmann A., Wang J., Song Z., Shi Y., Liu T., Li L., Zhou H., Wang Y., Zhang L., Wu H.-M., Lai L., Gu H., Dong J., Cheung A.Y., Dresselhaus T., and Qu L.-J.* 2022, RALF peptide signaling controls the polytubey block in Arabidopsis. Science 375 (6578): 290–296.
2. Li W., Li Q., Lyu M., Wang Z., Song Z., Zhong S., Gu H., Dong J., Dresselhaus T., Zhong S.*, Qu L.-J.* 2022, Lack of ethylene does not affect reproductive success and synergid cell death in Arabidopsis. Molecular Plant 15 (2): 354–362.
3. Hou S., Shi J., Hao L., Wang Z., Liao Y., Gu H., Dong J., Dresselhaus T., Zhong S.*, Qu L.-J.* 2021, VPS18-regulated vesicle trafficking controls the secretion of pectin and its modifying enzyme during pollen tube growth in Arabidopsis. Plant Cell 33: 3042–3056.
4. Ge Z., Zhao Y., Liu M.-C., Zhou L.-Z., Wang L., Zhong S., Hou S., Jiang J., Liu T., Huang Q., Xiao J., Gu H., Wu H.-M., Dong J., Dresselhaus T., Cheung A.Y., Qu L.-J.* 2019, LLG2/3 are co-receptors in BUPS/ANX-RALF signaling to regulate Arabidopsis pollen tube integrity. Current Biology 29: 3256–3265.
5. Zhong S., Liu M., Wang Z., Huang Q., Hou S., Xu Y.-C., Ge Z., Song Z., Huang J., Qiu X., Shi Y., Xiao J., Liu P., Guo Y.-L., Dong J., Dresselhaus T., Gu H., Qu L.-J.* 2019, Cysteine-rich peptides promote interspecific genetic isolation in Arabidopsis. Science 364: eaau9564.
6. Ge Z., Bergonci T., Zhao Y., Zou Y., Du S., Liu M.-C., Luo X., Ruan H., Garcia-Valencia L., Zhong S., Hou S., Huang Q., Lai L., Moura D., Gu H., Dong J., Wu H.-M., Dresselhaus T., Xiao J., Cheung A.*, Qu L.-J.* 2017, Arabidopsis pollen tube integrity and sperm release are regulated by RALF-mediated signaling. Science 358 (6370): 1596–1600.
7. Zhang J., Huang Q., Zhong S., Bleckmann A., Huang J., Guo X., Lin Q., Gu H., Dong J., Dresselhaus T., Qu L.-J.*, 2017, Sperm cells are passive cargo of the pollen tube in plant fertilization. Nature Plants 3: 17079.
8. Hou Y., Guo X., Cyprys P., Zhang Y., Bleckmann A., Cai L., Huang Q., Luo Y., Gu H., Dresselhaus T., Dong J., Qu L.-J.* 2016, Maternal ENODLs are required for pollen tube reception in Arabidopsis. Current Biology 26: 2343–2350.
9. Hao L., Liu J., Zhong S., Gu H., Qu L.-J.* 2016, AtVPS41-mediated endocytic pathway is essential for pollen tube-stigma interaction in Arabidopsis. Proceedings of the National Academy of Sciences, U. S. A. 113: 6307–6312.
10. Wu Z., Zhu D., Lin X., Miao J., Gu L., Deng X., Yang Q., Sun K., Zhu D., Cao X., Tsuge T., Dean C., Aoyama T., Gu H., Qu L.-J.* 2016, RNA-binding proteins RZ-1B and RZ-1C play critical roles in regulating pre-mRNA splicing and gene expression during development in Arabidopsis. Plant Cell 28: 55–73.
