研究方向
光是对于植物生长发育最重要的环境信号，本实验室多年来筛选获得了许多参与植物光形态建成的正向和负向调控因子，我们将深入解析这些因子之间的相互作用及其在光信号传导通路中的作用，我们还将寻找参与光信号通路的新因子，并探讨光与植物内源激素协同调控植物发育的机制。非编码RNA是不翻译成蛋白质而直接以RNA形式行使生物学功能的RNA分子，我们将探索中等长度非编码RNA参与和调控高等植物生长发育及环境信号响应的作用机理。杂种优势是杂交子一代在多个性状上优于其亲本的生物学现象，我们将以水稻和拟南芥为研究对象，在分子和细胞水平上解析杂种优势形成的遗传机理。我们还通过大数据的生物信息学分析和数学建模，开展水稻分子设计育种新技术的研究。
代表性科研论文
1. Wang, Y., Fan, Y., Fan, D., Zhou, X., Jiao, Y., Deng, X.W.*, and Zhu, D.* (2023). The noncoding RNA HIDDEN TREASURE 1 promotes phytochrome B-dependent seed germination by repressing abscisic acid biosynthesis. Plant Cell 35, 700-716.
2. Wang, J., Sun, N., Zheng, L., Zhang, F., Xiang, M., Chen, H., Deng, X.W.*, and Wei, N.* (2023). Brassinosteroids promote etiolated apical structures in darkness by amplifying the ethylene response via the EBF-EIN3/PIF3 circuit. Plant Cell 35, 390-408.
3. Wang, Y., Fan, Y., Fan, D., Zhang, Y., Zhou, X., Zhang, R., Wang, Y., Sun, Y., Zhang, W., He, Y., Deng, X.W.*, and Zhu, D.* (2022). The Arabidopsis DREAM complex antagonizes WDR5A to modulate histone H3K4me2/3 deposition for a subset of genome repression. Proc Natl Acad Sci U S A 119, e2206075119.
4. Liu, H., Wang, H., Liao, X.L., Gao, B., Lu, X., Sun, D., Gong, W., Zhong, J., Zhu, H., Pan, X., Guo, L., Deng, X.W.*, and Zhou, Q.* (2022). Mycoviral gene integration converts a plant pathogenic fungus into a biocontrol agent. Proc Natl Acad Sci U S A 119, e2214096119.
5. Liu, W., Zhang, Y., He, H., He, G.*, and Deng, X.W.* (2022). From hybrid genomes to heterotic trait output: Challenges and opportunities. Curr Opin Plant Biol 66, 102193.
6. Wang, Y., Wang, L., Guan, Z., Chang, H., Ma, L., Shen, C., Qiu, L., Yan, J., Zhang, D., Li, J., Deng, X.W.*, and Yin, P.* (2022). Structural insight into UV-B-activated UVR8 bound to COP1. Sci Adv 8, eabn3337.
7. Liu, W., He, G.*, and Deng, X.W.* (2021). Biological pathway expression complementation contributes to biomass heterosis in Arabidopsis. Proc Natl Acad Sci U S A 118.
8. Yang, L., Liu, P., Wang, X., Jia, A., Ren, D., Tang, Y., Tang, Y., Deng, X.W.*, and He, G.* (2021). A central circadian oscillator confers defense heterosis in hybrids without growth vigor costs. Nat Commun 12, 2317.
9. Feng, S., Martinez, C., Gusmaroli, G., Wang, Y., Zhou, J., Wang, F., Chen, L., Yu, L., Iglesias-Pedraz, J.M., Kircher, S., Schafer, E., Fu, X., Fan, L.M., and Deng, X.W.* (2008). Coordinated regulation of Arabidopsis thaliana development by light and gibberellins. Nature 451, 475-479.
10. Wang, H., Ma, L.G., Li, J.M., Zhao, H.Y., and Deng, X.W.* (2001). Direct interaction of Arabidopsis cryptochromes with COP1 in light control development. Science 294, 154-158.
11. Schwechheimer, C., Serino, G., Callis, J., Crosby, W.L., Lyapina, S., Deshaies, R.J., Gray, W.M., Estelle, M., and Deng, X.W.* (2001). Interactions of the COP9 signalosome with the E3 ubiquitin ligase SCFTIRI in mediating auxin response. Science 292, 1379-1382.
12. Osterlund, M.T., Hardtke, C.S., Wei, N., and Deng, X.W.* (2000). Targeted destabilization of HY5 during light-regulated development of Arabidopsis. Nature 405, 462-466.
13. Chamovitz, D.A., Wei, N., Osterlund, M.T., von Arnim, A.G., Staub, J.M., Matsui, M., and Deng, X.W. (1996). The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch. Cell 86, 115-121.
14. von Arnim, A.G., and Deng, X.W. (1994). Light inactivation of Arabidopsis photomorphogenic repressor COP1 involves a cell-specific regulation of its nucleocytoplasmic partitioning. Cell 79, 1035-1045.
15. Wei, N., Chamovitz, D.A., and Deng, X.W. (1994). Arabidopsis COP9 is a component of a novel signaling complex mediating light control of development. Cell 78, 117-124.
16. Deng, X.W., Matsui, M., Wei, N., Wagner, D., Chu, A.M., Feldmann, K.A., and Quail, P.H. (1992). COP1, an Arabidopsis regulatory gene, encodes a protein with both a zinc-binding motif and a G beta homologous domain. Cell 71, 791-801.
