研究方向
本实验室主要兴趣在于体细胞重编程、细胞命运调控和再生医学应用研究。我们的主要研究方向是如何通过细胞命运调控获得多潜能干细胞和各种功能性细胞。生命的本质是化学过程，化学小分子调控细胞命运理论上是最有效的方式。我们研究团队建立了化学小分子调控细胞命运的技术手段，首次利用化学小分子将小鼠体细胞诱导成为多潜能干细胞和功能性神经元，首次实现完全利用化学小分子制备人多潜能干细胞，不仅有助于更好地理解细胞命运决定和转变机制，而且为未来再生医学治疗重大疾病带来新的可能。我们团队利用化学小分子首次在体外建立了CiPS细胞和具有全能性特征的干细胞（EPS细胞），为体外制备各种功能成熟的细胞类型提供了更好的来源。我们将利用多潜能干细胞定向分化制备功能性的血液细胞、胰岛细胞、肝脏细胞，并结合基因编辑技术制备新型抗肿瘤的CAR-T细胞，为治疗重大疾病提供新的解决方案。
代表性科研论文
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