研究方向
化学与生命科学的交叉融合为分析、理解和操控生物学过程开辟了一条全新的研究途径。我们课题组的研究兴趣集中于化学糖生物学。我们开发化学方法，用以研究糖基化的生物学功能及其在相关人类疾病中的作用。主要研究内容包括：
1. 活细胞和活体中聚糖的化学标记、成像及组学分析
2. 脑部糖基化的生理及病理功能
3. 糖基化在蛋白质-RNA相互作用中的功能
4. 生物大分子（糖、蛋白、核酸）的代谢标记方法开发
代表性科研论文
1. Gao, L.; Song, Q.; Liang, H.; Zhu, Y.; Wei, T.; Dong, N.; Xiao, J.; Shao, F.; Chen, X.* “Legionella Effector SetA as A General O-glucosyltransferase for Eukaryotic Proteins” Nat. Chem. Biol. 15, 213-216 (2019).
2. Huang, R.; Han, M.; Meng, L.; Chen, X.* “Transcriptome-Wide Discovery of Coding and Noncoding RNA-Binding Proteins” Proc. Natl. Acad. Sci. USA 115, E3879-E3887 (2018).
3. Sun, Y.; Hong, S.; Xie, R.; Huang, R.; Lei, R.; Cheng, B.; Sun, D.; Du, Y.; Nycholat, C.; Paulson, J.; Chen, X.* “Mechanistic Investigation and Multiplexing of Liposome-Assisted Metabolic Glycan Labeling” J. Am. Chem. Soc. 140, 3592-3602 (2018).
4. Qin, W.; Qin, K.; Fan, X.; Peng, L.; Hong, W.; Zhu, Y.; Lv, P.; Du, Y.; Huang, R.; Han, M.; Cheng, B.; Liu, Y.; Zhou, W.; Wang, C.*; Chen, X.* “Artifical Cysteine S-Glycosylation Induced by Per-O-Acetylated Unnatural Monosaccharides during Metabolic Glycan Labeling” Angew. Chem. Int. Ed. 57, 1817-1820 (2018).
5. Qin, W.; Lv, P.; Fan, X.; Quan, B.; Zhu, Y.; Qin, K.; Chen, Y.; Wang, C.*; Chen, X.* “Quantitative Time-Resolved Chemoproteomics Reveals Stable O-GlcNAc Regulates Box C/D snoRNP Biogenesis” Proc. Natl. Acad. Sci. USA 114, E6749-E6758 (2017).
6. Zhu, Y.; Wu, J.; Chen, X.* “Metabolic Labeling and Imaging of N-Linked Glycans in Arabidopsis Thaliana” Angew. Chem. Int. Ed 55, 9301-9305 (2016).
7. Xie, R.; Dong, L.; Du, Y.; Zhu, Y.; Hua, R.; Zhang, C.; Chen, X.* “In Vivo Metabolic Labeling of Sialoglycans in the Mouse Brain By Using A Liposome-Assisted Bioorthogonal Reporter Strategy” Proc. Natl. Acad. Sci. USA 113, 5173-5178 (2016).
8. Lin, L.; Liu, L.; Zhao, B.; Xie, R.; Lin, W.; Li, H.; Li, Y.; Shi, M.; Chen, Y.; Springer, T. A.; Chen, X.* “Carbon Nanotube-Assisted Optical Activation of TGF- Signaling by Near-Infrared Light” Nat. Nanotech. 10, 465-471 (2015).
