宋晨

研究方向：

宋晨研究组从事计算生物物理化学研究：运用多尺度计算模拟，研究离子通道等膜蛋白的微观功能机理，定量理解跨膜信号转导和物质转运过程；利用深度学习等方法，对膜蛋白的性质、结构和功能进行预测；探索膜蛋白的设计与改造等。

代表性科研论文：

1. Kang, K.^†; Wang, L. ^†; Song, C.* ProtRAP: Predicting Lipid Accessibility Together with Solvent Accessibility of Proteins in One Run. J. Chem. Inf. Model. 2023, 63, 1058-1065.

2. Wang, L.; Zhang, J.; Wang, D.; Song, C.* Membrane Contact Probability: An Essential and Predictive Character for the Structural and Functional Studies of Membrane Proteins. PLoS Comput. Biol. 2022, 18, e1009972.

3. Wang, Y.^†; Guo, Y.^†; Li, G.; Liu, C.; Wang, L.; Zhang, A.; Yan, Z.*; Song, C.* The Push-to-Open Mechanism of the Tethered Mechanosensitive Ion Channel NompC. eLife 2021, 10, e58388.

4. Zhang, A.; Yu, H.; Liu, C.; Song, C.* The Ca²⁺ Permeation Mechanism of the Ryanodine Receptor Revealed by a Multi-Site Ion Model. Nat. Commun. 2020, 11, 922.

5. Zhang, M.; Wang, D.; Kang, Y.; Wu, J.-X.; Yao, F.; Pan, C.; Yan, Z.*; Song, C.*; Chen, L.* Structure of the Mechanosensitive OSCA Channels. Nat. Struct. Mol. Biol. 2018, 25, 850–858.

6. Köpfer, D. A.^†; Song, C.^†*; Gruene, T.; Sheldrick, G. M.; Zachariae, U.*; de Groot, B. L.* Ion Permeation in K⁺ Channels Occurs by Direct Coulomb Knock-On. Science 2014, 346, 352–355.