研究方向:白凡实验室致力于创新和应用单细胞、单分子技术,探索生物医学前沿交叉领域,关注癌症发生、基因突变和转移机制,关注细菌致病和抗生素耐药的分子机制。已在Science(2篇),Nature,Cell(2篇),Cancer Cell,Nature Immunology,Molecular Cell(2篇)等著名学术期刊发表论文100余篇,曾获得中组部“青年海外高层次人才”计划,基金委优秀青年基金(2017),杰出青年基金(2021)。以课题负责人多次获得科技部863计划、“精准医学”重点研发计划、科技重大专项资助,获得国家科技进步二等奖,中国细胞生物学学会-青年科学家奖,树兰医学青年奖,中源协和创新突破奖。研究成果获Cell杂志社2019年中国年度论文,获2019年中国临床医学十大进展。
代表性科研论文:
1. Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 2020, 370/6512/82-89
2. A body map of somatic mutagenesis in morphologically normal human tissues, Nature 2021, 597/7876/398-403
3. Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 2019, 5/179/1160-1176
4. Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia, Cell 2020, 183/7/1867-1883
5. Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes, Cancer Cell 2019, 6/35/ 932-947