研究方向：干细胞生物学，RNA生物学，基因编辑
研究领域主要为干细胞和RNA生物学。主要成果包括建立了miRNA全敲除小鼠胚胎干细胞系，率先揭示了miRNA通路对于胚胎干细胞增殖与分化的重要作用；发现了调控胚胎干细胞增殖、细胞周期、糖酵解代谢和自我更新等功能的miR-290和miR-302家族并解析了其分子机制；发明了miRNA激活CRISPR-Cas9基因编辑体系开启的技术平台，以及新型非编码RNA启动子活性报告基因技术；鉴定了调控FGF/ERK通路活性的长非编码RNA，解析了其促进胚胎干细胞自我更新的功能和分子机制；发现了调控早期胚胎发育合子基因组激活（ZGA）和体外全能干细胞转化的新分子通路PIAS4-SUMO2-DPPA2/4；发现了新的双链DNA脱氨酶并基于此开发了新的线粒体碱基编辑器。在学术杂志Nature Genetics、Nature Cell Biology、Nature Communications、EMBO Journal、Cell Research和PLoS Biology等以第一或通讯作者发表学术论文30余篇，总引用5000余次。实验室最近聚焦方向包括早期胚胎发育、类器官疾病模型和RNA靶向药物研究。
代表性科研论文：
1. Mi, L., Shi, M., Li, Y.X., Xie, G., Rao, X., Wu, D., Cheng, A., Niu, M., Xu, F., Yu, Y., Gao, N., Wei, W., Wang, X. and *Wang, Y. (2023) DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing. Nature Communications, 14, 874.
2. Wang, S.H., Hao, J., Zhang, C., Duan, F.F., Chiu, Y.T., Shi, M., Huang, X., Yang, J., *Cao, H. and *Wang, Y. (2022) Klf17 promotes human naive pluripotency through repressing MAPK3 and ZIC2. Science China Life Sciences, 65, 1985-1997.
3. Zhao, Y.T. and *Wang, Y. (2021) Monitoring the promoter activity of long noncoding RNAs and stem cell differentiation through knock-in of sgRNA flanked by tRNA in an intron. Cell Discovery, 7, 45.
4. #Yan, Y.L, #Zhang, C., Hao, J., Wang, X.L., Ming, J., Mi, L., Na, J., Hu, X. and *Wang，Y. (2019) DPPA2/4 and SUMO E3 ligase PIAS4 opposingly regulate zygotic transcriptional program. PLOS Biology 17, e3000324.
5. #Wang, X.W., #Hu, L.F., Hao, J., Liao, L.Q., Chiu, Y.T., Shi, M. and *Wang，Y. (2019) A microRNA-inducible CRISPR-Cas9 platform serves as a microRNA sensor and cell-type-specific genome regulation tool. Nature Cell Biology 21, 522-530. (Highlighted by News and Views in Nature Cell Biology, 21, 416-417)
6. #Li, Y.P., #Duan, F.F., Zhao, Y.T., Gu, K.L., Liao, L.Q., Su, H.B., Hao, J., Zhang, K., Yang, N. and *Wang，Y. (2019) A TRIM71 binding long noncoding RNA Trincr1 represses FGF/ERK signaling in embryonic stem cells. Nature Communications 10, 1368.
