研究方向：
研究组建立和开发组学实验新技术，与学科交叉的实验室合作，研究细胞命运调控。采用高通量实验技术和计算方法相结合的手段，系统开展了细胞命运调控的三维基因组与多组学研究。发现了加速干细胞重编程和治疗难治性肿瘤的新靶点，为三维基因组学发展了新技术，为染色质高级结构参与细胞命运调控研究开拓了新视角。
1、细胞命运调控（Nat Immunol 2020, Cell Stem Cell 2018, Cancer Cell 2017, Cell Res 2021, 2022a, 2022b）
2、三维基因组技术（Cell 2021, Cell Res 2022c, Nat Commun 2017, 2023, Cell Reports 2020, 2022, Genome Biology 2018）
3、蛋白质组学技术
代表性科研论文：
Mapping nucleolus-associated chromatin interactions using nucleolus Hi-C reveals pattern of heterochromatin interactions. Peng T✯, Hou Y✯, Meng H✯, Cao Y, Wang X, Jia L, Chen Q, Zheng Y, Sun Y, Chen H, Li T*, Li C*. Nat Commun. 2023. 14(1):350.
CTCF organizes inter-A compartment interactions through RYBP-dependent phase separation. Wei C✯, Jia L✯, Huang X✯, Tan J✯, Wang M, Niu J, Hou Y, Sun J, Zeng P, Wang J, Qing L, Ma L, Liu X, Tang X, Li F, Jiang S, Liu J, Li T, Fan L, Sun Y, Gao J, Li C*, Ding J*. Cell Res. 2022c. 32(8):744-760.
3D Genome of macaque fetal brain reveals evolutionary innovations during primate corticogenesis. Luo X✯, Liu Y✯, Dang D✯, Hu T, Hou Y, Meng X, Zhang F, Li T, Wang C, Li M, Wu H, Shen Q, Hu Y, Zeng X, He X, Yan L, Zhang S*, Li C*, Su B*. Cell. 2021. 184(3):723-740.e21.
Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection. Xie X✯, Shi Q✯, Wu P, Zhang X, Kambara H, Su J, Yu H, Park SY, Guo R, Ren Q, Zhang S, Xu Y, Silberstein LE, Cheng T, Ma F*, Li C*, Luo HR*. Nat Immunol. 2020. 21(9):1119-1133.
tagHi-C Reveals 3D Chromatin Architecture Dynamics during Mouse Hematopoiesis. Zhang C✯, Xu Z✯, Yang S✯, Sun G✯, Jia L, Zheng Z, Gu Q, Tao W*, Cheng T*, Li C*, Cheng H*. Cell Rep. 2020. 32(13):108206.
