研究方向：鉴定影响肿瘤发生发展和转移新的调控蛋白，揭示泛素化、类泛素化、乙酰化等蛋白质翻译后修饰在DNA损伤应答、基因组稳定性维持、肿瘤细胞耐药、肿瘤代谢和免疫调控中的作用和分子机制。
代表性科研论文：
1. Zhuge RP, Wang C, Wang J, Yu SY, Liao LM, Zheng XF*. (2023) hCINAP controls lineage differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase separation-mediated YAP1 activation. Cell Reports..42(1) 111935.
2. Zhu D, Xu R, Huang X, Tang Z, Tian Y, Zhang J, Zheng XF*. (2021) Deubiquitinating enzyme OTUB1 promotes cancer cell immunosuppression via preventing ER-associated degradation of immune checkpoint protein PD-L1. Cell Death & Differentiation. 28:1773–1789.
3. Yang YF, Yang CZ, Li TT, Yu SY, Cui J, Zheng XF*. (2020) The deubiquitinase USP38 promotes NHEJ repair through regulation of HDAC1 activity and regulates cancer cell response to genotoxic insults. Cancer Research. 80 (4): 719-731.
4. Zang WC, Yang CZ. Li TT, Liao LM, Zheng XF*. (2019) Cellular redox sensor HSCARG negatively regulates the translesion synthesis pathway and exacerbates mammary tumorigenesis. Proc.Natl.Acad.Sci.USA.116 (51): 25624-25633.
5. Xu RD, Yu SY, Zhu D, Huang XP, Lao YM, Zhang JF, Tang ZF, Zhang ZM, Yi J, Zhu HH, Zhu, Zheng XF*. (2019) hCINAP regulates the DNA damage response and mediates the resistance of acute myelocytic leukemia cells to therapy. Nature Communications. 10:3812.
6. Yang CZ, Zang WC, Tang ZF, Ji YP, Xu RD, Yang YF, Luo AP, Hu B, Zhang ZM, Liu ZH, Zheng XF*. (2018) A20 regulates the DNA damage response and mediates tumor cell resistance to DNA damaging therapy. Cancer Research. 78(4): 1069-1082.
7. Ji YP, Yang CZ, Tang ZF, Yang YF, Tian YL, Yao HW, Zhu X, Zhang ZM, Ji JF, Zheng XF*. (2017) Adenylate kinase hCINAP determines self-renewal of colorectal cancer stem cells in a glycolysis-dependent manner by facilitating LDHA phosphorylation. Nature Communications. 8:15308.
8. Bai DM, Zhang J, Li T, Hang R, Liu Y, Tian Y, Huang D, Qu L, Cao XF, Ji J-F, Zheng XF*. (2016) The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumor growth. Nature Communications.7: 12310.
9. Hu B, Li SZ, Zhang XD, Zheng XF*. (2014) HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation. Nucleic Acids Research. 42, 5582-5593
10. Bai DM, Zhang J, Xiao WC, Zheng XF*. (2014) Regulation of the HDM2-p53 pathway by ribosomal protein L6 in response to ribosomal stress. Nucleic Acids Research. 42(3):1799-1811.
