研究方向：
B细胞介导的体液免疫是人体抵御外来病原的重要机制。深入理解适应性体液免疫应答是开发传染病广谱抗体药物和高效广谱疫苗的关键。本实验室主要聚焦B细胞适应性免疫应答与抗体抗原相互作用，开展以下科学问题的研究与探索：1）基于中和抗体高通量表征的新冠病毒免疫逃逸突变预测；2）针对呼吸道传染性病毒（如新冠、流感等）广谱黏膜疫苗设计与广谱抗体药物研制；3）体液免疫印迹、免疫衰减和免疫记忆的分子机制研究；4）基于高通量实验数据与机器学习模型的抗原表位特异性抗体人工设计。
代表性科研论文：
1. Y. Cao*#, F. Jian#, J. Wang#, Y. Yu#, W. Song#, A. Yisimayi, J. Wang, R. An, X.Chen, N. Zhang, Y. Wang, P. Wang, L. Zhao, H. Sun, L. Yu, S. Yang, X. Niu, T. Xiao, Q. Gu, F. Shao, X. Xiao, Y. Xu, R. Jin, Z. Shen, Y. Wang* & X. S. Xie*, Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution. Nature 614: 21-529 (2022).
2. Y. Cao*#, A. Yisimayi#, F. Jian#, W. Song#, T. Xiao#, L. Wang#, S. Du#, J. Wang#, Q. Li#, X. Chen#, Y. Yu#, P. Wang, Z. Zhang, P. Liu, R. An, X. Hao, Y. Wang, J. Wang, R. Feng, H. Sun, L. Zhao, W. Zhang, D. Zhao, J. Zheng, L. Y, C. Li, N. Zhang, R. Wang, X. Niu, S. Yang, X. Song, Y. Chai, Y. Hu, Y. Shi, L. Zheng, Z. Li, Q. Gu, F. Shao, W. Huang, R. Jin, Z. Shen*, Y. Wang*, X. Wang*, J. Xiao* & X. S. Xie*, BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature 608: 593-602 (2022).
3. Y. Cao*#, J. Wang#, F. Jian#, T. Xiao#, W. Song#, A. Yisimayi#, W. Huang#, Q. Li, P. Wang, R. An, J. Wang, Y. Wang, X. Niu, S. Yang, H. Liang, H. Sun, T. Li, Y. Yu, Q. Cui, S. Liu, X. Yang, S. Du, Z. Zhang, X. Hao, F. Shao, R. Jin, X. Wang*, J. Xiao*, Y. Wang* & X. S. Xie*, Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies. Nature 602: 657-663 (2022).
4. Z. Cui#, P. Liu#, N. Wang#, L. Wang#, K. Fan#, Q. Zhu#, K. Wang#, R. Chen, R. Feng, Z. Jia, M. Yang, G. Xu, B. Zhu, W. Fu, T. Chu, L. Feng, Y. Wang, X. Pei, P. Yang, X. S. Xie, L. Cao*, Y. Cao*, X. Wang*, Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron. Cell 185(5): 860-871 (2022).
5. S. Du#, Y. Cao#, Q. Zhu#, P. Yu#, F. Qi#, G. Wang, X. Du, L. Bao, W. Deng, H. Zhu, J. Liu, J. Nie, Y. Zheng, H. Liang, R. Liu, S. Gong, H. Xu, A. Yisimayi, Q. Lv, B. Wang, R. He, Y. Han, W. Zhao, Y. Bai, Y. Qu, X. Gao, C. Ji, Q. Wang, N. Gao, W. Huang, Y. Wang, X. S. Xie*, X. Su*, J. Xiao*, C. Qin*, Structurally Resolved SARS-CoV-2 Antibody Shows High Efficacy in Severely Infected Hamsters and Provides a Potent Cocktail Pairing Strategy. Cell 183: 1013-1023.e13 (2020).
6. Y. Cao#, B. Su#, X. Guo#, W. Sun#, Y. Deng#, L. Bao#, Q. Zhu, X. Zhang, Y. Zheng, C. Geng, X. Chai, R. He, X. Li, Q. Lv, H. Zhu, W. Deng, Y. Xu, Y. Wang, L. Qiao, Y. Tan, L. Song, G. Wang, X. Du, N. Gao, J. Liu, J. Xiao, X. Su, Z. Du, Y. Feng, C. Qin*, C. Qin*, R. Jin*, X. S. Xie*, Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells. Cell 182, 73-84.e16 (2020).
