研究方向：DNA损伤修复与肿瘤
代表性科研论文：
1. Chen J, Lu Z, Gong W, Xiao X, Feng X, Li W, Shan S, Xu D*, Zhou Z*. Epstein-Barr virus protein BKRF4 restricts nucleosome assembly to suppress host antiviral responses. Proc Natl Acad Sci U S A. 2022 Sep 13;119(37): e2203782119.
2. Feng S, Ma S, Li K, Gao S, Ning S, Shang J, Guo R, Chen Y, Blumenfeld B, Simon I, Li Q, Guo R, Xu D*. RIF1-ASF1-mediated high-order chromatin structure safeguards genome integrity. Nature Communications. 2022;13(1):957
3. Xu X, Xu Y*, Guo R, Xu R, Fu C, Xing M, Sasanuma H, Li Q, Takata M, Takeda S, Guo R* and Xu D*. Fanconi anemia proteins participate in a break-induced-replication-like pathway to counter replication stress. Nat Struct Mol Biol 2021 Jun;28(6):487-500.
4. Li W, Bai X, Li J, Zhao Y, Liu J, Zhao H, Liu L, Ding M, Wang Q, Shi F-Y, Hou M, Ji J, Gao G, Guo R, Sun Y, Liu Y*, Xu D*. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nature Cell Biology. 2019; 21 (10): 1273-1285.
5. Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R*, Xu D*. A mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A. 2018 115(43): E10079-E10088
6. Gao S, Feng S, Ning S, Liu J, Zhao H, Xu Y, Shang J, Li K, Li Q, Guo R*, Xu D*. An OB-fold complex controls the repair pathways for DNA double-strand breaks. Nature Communications 2018;9(1):3925
7. Xu Y, Ning S, Wei Z, Xu R, Xu X, Xing M, Guo R* and Xu D*. 53BP1 and BRCA1 control pathway choice for stalled replication restart. Elife 2017 Nov 6;6. pii: e30523.
